profile Lingyun (Ivy) Xiong, D.Phil.

Postdoctoral Fellow at UCLA
Integrative Biology and Physiology
Quantitative and Computational Biosciences

Research Collaborator at NIH/NCI

Founder and Host of the Dynamics Club
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Email: ivyxiong@ucla.edu

Homeodynamics in Health and Disease

I aim to understand the mechanisms and functions of oscillatory behaviors in systems physiology. Oscillatory processes permeate every branch of biology, from circadian rhythms at the molecular level, cell motility at the cellular and tissue level, hormonal regulation across organ systems, to circadian coordination of physical activities at the organismal level. However, how oscillatory signals impact organ functions is poorly understood. My current research addresses this gap by focusing on physiological oscillations in the mammalian kidney. I take a multi-scale approach to investigate how tubular fluid flow and cellular metabolic dynamics are coupled to facilitate normal physiology in the kidney, how oscillatory flow in 1 million renal tubules coordiantes to achieve organ-level temporal synchronization, and more broadly how oscillatory signals can organize multi-organ communication. Combining quantitative imaging and mathematical modeling, my onging research evaluates the mathematical structures underlying the transition from health to disease.

Current Research Focus

  • Physiological dynamics via in vivo imaging and telemetry
  • Computational modeling of fluid dynamics
  • Comparative studies of cardio-renal physiology

Qualifications

  • D.Phil. in Systems Biology, University of Oxford (2021)
  • B.Sc. in Biochemistry, University of Hong Kong (2016)
  • Study abroad in Biology, University of California, San Diego (2015)

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