Publications

§ Equal contribution, # Corresponding author

• Cell fate transition as a coordinated bifurcation event
  Lingyun Xiong (In Preparation)

• Studying the effects of oral contraceptives on coagulation using a mathematical model
  Amy Kent, Karin Leiderman, Anna C. Nelson, Suzanne Sindi, Melissa M. Stadt, Lingyun Xiong, Ying Zhang.
  Mathematical Modeling for Women’s Health (Springer Nature Switzerland), 2024;166:83–132. DOI: 10.1007/978-3-031-58516-6_4 (PDF)

• Sexual dimorphism in renal metabolism, hemodynamics and diseases
  Lingyun Xiong#, Alan Garfinkel, Eric J. Deeds.
  Physiology, 2024;39(S1):1234. DOI: 10.1152/physiol.2024.39.S1.1234

• Sex differences in renal transporters: assessment and functional consequences
  Alicia A. McDonough, Autumn N. Harris, Lingyun Xiong, Anita T. Layton.
  Nat Rev Nephrol, 2024;20(1):21-36. DOI: 10.1038/s41581-023-00757-2 (PDF)

• Direct androgen receptor control of sexually dimorphic gene expression in the mammalian kidney
  Lingyun Xiong§, Jing Liu§, Sueng Yub Han, Kari Koppitch, Jin-Jin Guo, Megan Rommelfanger, Zhen Miao, Fan Gao, Ingileif Hallgrimsdottir, Lior Pachter, Junhyong Kim, Adam L. MacLean, Andrew P. McMahon.
  Dev Cell, 2023;58(21):2338-2358.e5. DOI: 10.1016/j.devcel.2023.08.010 (PDF)

• Are physiological oscillations physiological?
  Lingyun Xiong, Alan Garfinkel.
  J Physiol, 2023 Aug 25 (Online ahead of print). DOI: 10.1113/JP285015 (PDF)

• Sex differences in proximal tubule metabolism influence hemodynamics and salt reabsorption to mediate dimorphic susceptibility to kidney diseases
  Lingyun Xiong#, Adam L. MacLean, Andrew P. McMahon.
  Physiology, 2023;38(S1):5731763. DOI: 10.1152/physiol.2023.38.S1.5731763

• Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer
  Anna J. Wiecek, Stephen J. Cutty, Daniel Kornai, Mario Parreno-Centeno, Lucie E. Gourmet, Guidantonio Malagoli Tagliazucchi, Daniel H. Jacobson, Ping Zhang, Lingyun Xiong, Gareth Bond, Alexis R. Barr, Maria Secrier.
  Genome Biol, 2023;24(1):128. DOI: 10.1186/s13059-023-02963-4 (PDF)

• A common pathway to cancer: Oncogenic mutations abolish p53 oscillations
  Lingyun Xiong, Alan Garfinkel.
  Prog Biophys Mol Biol, 2022 Oct;174:28-40. DOI: 10.1016/j.pbiomolbio.2022.06.002 (PDF)

• Influence of inherited genetic variants on risk, biology and prognosis of common cancers
  Lingyun Xiong
  PhD thesis, University of Oxford, 2021

• Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression, and drug response
  Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Giovanni Stracquadanio, Katherine Brown, Philipp Richter, Marsha Wallace, Elisabeth Bond, Natasha Sahgal, Samantha Moore, Svanhild Nornes, Sarah De Val, Mirvat Surakhy, David Sims, Xuting Wang, Douglas A Bell, Jorge Zeron-Medina, Yanyan Jiang, Anderson Ryan, Joanna Selfe, Janet Shipley, Siddhartha Kar, Paul Pharoah, Chey Loveday, Rick Jansen, Lukasz F. Grochola, Claire Palles, Andrew Protheroe, Val Millar, Daniel Ebner, Meghana Pagadala, Sarah P Blagden, Tim Maughan, Enric Domingo, Ian Tomlinson, Clare Turnbull, Hannah Carter, Gareth Bond.
  Cancer Res, 2021;81:1667–1680. DOI: 10.1158/0008-5472.CAN-20-0177 (PDF)

• Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits
  Matteo Di Giovannantonio, Benjamin H.L. Harris, Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Natasha Sahgal, Giovanni Stracquadanio, Marsha Wallace, Sarah Blagden, Simon Lord, David A. Harris, Adrian Harris, Francesca M. Buffa, Gareth Bond.
  J Med Genet, 2020;0:1–8. DOI: 10.1136/jmedgenet-2019-106799

• SALL4 promotes glycolysis and chromatin remodelling via modulating HP1α-Glut1 pathway
  Jinchul Kim, Shuxiang Xu, Lingyun Xiong, Lily Yu, Xuemei Fu, Yang Xu.
  Oncogene, 2017;36(46):6472–6479. DOI: 10.1038/onc.2017.265 (PDF)

Preprints

• Learning feedback loops in transcriptome network during cell fate transition
  Lingyun Xiong#, William A. Schoenberg, Jeremy D. Swartz.
  bioRxiv, 2024. DOI: 10.1101/2020.06.24.169490v2

• Gene regulatory network inference with popInfer reveals dynamic regulation of hematopoietic stem cell quiescence upon diet restriction and aging
  Megan K Rommelfanger, Marthe Behrends, Yulin Chen, Jonathan Martinez, Martin Bens,
  Lingyun Xiong, K Lenhard Rudolph, Adam L. MacLean
  bioRxiv, 2023. DOI: 10.1101/2023.04.18.537360